The organisation said 1,667 civilians and 361 police across eight governorates have been injured. Fifty-three civilians and three police officers have died.
Moreover, 35 governmental institutions and 13 private institutions have been attacked.
Until Wednesday, 450 protesters had been detained, with 70 released pending investigations.
An EOHR fact-finding committee went to Port Said, Ismailiya, Suez, Alexandria, Beheira, Sharqiya, Cairo and Gharbeya. During these visits, 75 testimonies were collected from eyewitnesses, injured people recovering in hospital, government officials, and heads of government hospitals.
The organisation called for a committee to be formed to hold guilty persons accountable.
The right to peaceful protest is protected by international human rights law, it added.
There must be an inclusive national dialogue to end the wave of bloodshed and stop it from happening again, the organisation said.
At a press conference to launch the report on Wednesday, EOHR member Mohamed El-Domiaty condemned the torture of protester Hamada Saber outside the presidential palace on 1 February, which was aired live by Al-Hayat television channel.
A number of examples of alleged torture by police have come to light in recent weeks, including the killing of leftist activist Mohamed El-Gendy.
On Wednesday, the presidential office said it would not remain silent on human rights abuses, in reference to the death of El-Gendy.